abstract：OBJECTIVE:Scottish fold cats, named for their unique ear shape, have a dominantly inherited osteochondrodysplasia involving malformation in the distal forelimbs, distal hindlimbs and tail, and progressive joint destruction. This study aimed to identify the gene and the underlying variant responsible for the osteochondr...

journal_title：Osteoarthritis and cartilage

authors： Gandolfi B,Alamri S,Darby WG,Adhikari B,Lattimer JC,Malik R,Wade CM,Lyons LA,Cheng J,Bateman JF,McIntyre P,Lamandé SR,Haase B

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:To characterize the initial events in the cleavage of type II collagen mediated by cathepsin K and demonstrate the presence of the resulting products in human and equine articular osteoarthritic cartilage. DESIGN:Equine type II collagen was digested with cathepsin K and the cleavage products characterized by...

journal_title：Osteoarthritis and cartilage

authors： Mort JS,Beaudry F,Théroux K,Emmott AA,Richard H,Fisher WD,Lee ER,Poole AR,Laverty S

更新日期：2016-08-01 00:00:00

abstract：OBJECTIVE:Semicarbazide-sensitive amine oxidase (SSAO) catalyzes the oxidation of primary amines into ammonia and reactive species (hydrogen peroxide, aldehydes). It is highly expressed in mammalian tissues, especially in vascular smooth muscle cells and adipocytes, where it plays a role in cell differentiation and glu...

journal_title：Osteoarthritis and cartilage

authors： Filip A,Pinzano A,Bianchi A,Fève B,Jalkanen S,Gillet P,Mainard D,Lacolley P,Magdalou J,Mercier N

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Exercise is vital for maintaining cartilage integrity in healthy joints. Here we examined the exercise-driven transcriptional regulation of genes in healthy rat articular cartilage to dissect the metabolic pathways responsible for the potential benefits of exercise. METHODS:Transcriptome-wide gene expression...

journal_title：Osteoarthritis and cartilage

authors： Blazek AD,Nam J,Gupta R,Pradhan M,Perera P,Weisleder NL,Hewett TE,Chaudhari AM,Lee BS,Leblebicioglu B,Butterfield TA,Agarwal S

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Abnormal metabolic activities of chondrocytes may cause articular cartilage (AC) degradation, but key transcription factors regulating metabolic activities in AC of aging individuals remain unknown. This study aimed to investigate the role of transcription factor NFAT1 in regulating the expression of anabolic...

journal_title：Osteoarthritis and cartilage

authors： Zhang M,Lu Q,Egan B,Zhong XB,Brandt K,Wang J

更新日期：2016-07-01 00:00:00

abstract：OBJECTIVE:Cam hip shape morphology is a recognised cause of femoroacetabular impingement (FAI) and is associated with hip osteoarthritis. Our aim was to systematically review the available epidemiological evidence assessing the prevalence of cam hip shape morphology in the general population and any studied subgroups i...

journal_title：Osteoarthritis and cartilage

authors： Dickenson E,Wall PD,Robinson B,Fernandez M,Parsons H,Buchbinder R,Griffin DR

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVES:Using a mouse surgical model of post-traumatic osteoarthritis (OA), we sought to determine if muscle function is altered following acute joint injury and whether this relates to OA progression. DESIGN:Male C57BL/6 mice underwent surgical transection of the medio-meniscal tibial ligament destabilisation of t...

journal_title：Osteoarthritis and cartilage

authors： van der Poel C,Levinger P,Tonkin BA,Levinger I,Walsh NC

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:Summarize the comparative effectiveness of oral non-steroidal anti-inflammatory drugs (NSAIDs) and opioids in reducing knee osteoarthritis (OA) pain. METHODS:Two reviewers independently screened reports of randomized controlled trials (RCTs), published in English between 1982 and 2015, evaluating oral NSAIDs...

journal_title：Osteoarthritis and cartilage

authors： Smith SR,Deshpande BR,Collins JE,Katz JN,Losina E

更新日期：2016-06-01 00:00:00

abstract：OBJECTIVE:To determine prevalence, incidence and progression of radiographic knee osteoarthritis (OA) in a cohort of subjects with previous meniscectomy. METHODS:We assessed 221 subjects (177 men and 44 women) with weight bearing knee radiography twice (assessment A and B) with a follow-up time ranging from 4 to 10 ye...

journal_title：Osteoarthritis and cartilage

authors： Paradowski PT,Lohmander LS,Englund M

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:To determine in human articular chondrocytes the activity of Aldehyde dehydrogenase (ALDH), which are reported as stem/progenitor cell marker in various adult tissues and evaluate gene expression of ALDH1A isoforms. DESIGN:ALDH activity was evaluated by flow cytometry with Aldefluor™ assay in cells, isolated...

journal_title：Osteoarthritis and cartilage

authors： Unguryte A,Bernotiene E,Bagdonas E,Garberyte S,Porvaneckas N,Jorgensen C

更新日期：2016-05-01 00:00:00

abstract：OBJECTIVE:Notch signaling has been identified as a critical regulator in cartilage development and joint maintenance, and loss of Notch signaling in all joint tissues results in an early and progressive osteoarthritis (OA)-like pathology. This study investigated the targeted cell population within the knee joint in whi...

journal_title：Osteoarthritis and cartilage

authors： Liu Z,Ren Y,Mirando AJ,Wang C,Zuscik MJ,O'Keefe RJ,Hilton MJ

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Animal models are frequently used to study post-traumatic osteoarthritis (PTOA). A common anterior cruciate ligament (ACL) injury model is surgical transection, which may introduce confounding factors from surgery. Noninvasive models could model human injury more closely. The purpose of this study was to comp...

journal_title：Osteoarthritis and cartilage

authors： Maerz T,Kurdziel M,Newton MD,Altman P,Anderson K,Matthew HW,Baker KC

更新日期：2016-04-01 00:00:00

abstract：INTRODUCTION:Osteoarthritis (OA) is a common disease worldwide leading to significant morbidity. The underlying disease process is multifactorial however there is increasing focus on molecular mechanisms. MicroRNAs are small non-coding segments of RNA that have important regulatory functions at a cellular level. These ...

journal_title：Osteoarthritis and cartilage

authors： Nugent M

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Prevalence of ankle osteoarthritis (OA) is lower than that of knee OA, however, the molecular mechanisms underlying the difference remain unrevealed. In the present study, we developed mouse ankle OA models for use as tools to investigate pathophysiology of ankle OA and molecular characteristics of ankle cart...

journal_title：Osteoarthritis and cartilage

authors： Chang SH,Yasui T,Taketomi S,Matsumoto T,Kim-Kaneyama JR,Omiya T,Hosaka Y,Inui H,Omata Y,Yamagami R,Mori D,Yano F,Chung U,Tanaka S,Saito T

更新日期：2016-04-01 00:00:00

abstract：OBJECTIVE:Allogeneic cell therapies, such as mesenchymal stromal cells (MSC), which have potent regenerative and anti-inflammatory potential are being investigated as a therapy for osteoarthritis (OA) and cartilage injury. Here we describe another potential source of regenerative and anti-inflammatory allogeneic cells,...

journal_title：Osteoarthritis and cartilage

authors： Lohan P,Treacy O,Lynch K,Barry F,Murphy M,Griffin MD,Ritter T,Ryan AE

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To investigate patterns of MRI abnormalities in the patellofemoral (PFJ) and tibiofemoral joint (TFJ) and their association with radiographic progression, using hypothesis free analyses. DESIGN:205 patients from the GARP study with symptomatic OA at multiple sites (mean age 60 years, 80% woman, median BMI 26...

journal_title：Osteoarthritis and cartilage

authors： de Lange-Brokaar BJ,Bijsterbosch J,Kornaat PR,Yusuf E,Ioan-Facsinay A,Zuurmond AM,Kroon HM,Meulenbelt I,Bloem JL,Kloppenburg M

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVES:The generation of transgenic mice expressing green fluorescent proteins (GFPs) has greatly aided our understanding of the development of connective tissues such as bone and cartilage. Perturbation of a biological system such as the temporomandibular joint (TMJ) within its adaptive remodeling capacity is part...

journal_title：Osteoarthritis and cartilage

authors： Utreja A,Dyment NA,Yadav S,Villa MM,Li Y,Jiang X,Nanda R,Rowe DW

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:To determine T2* relaxation in articular cartilage using ultrashort echo time (UTE) imaging and bi-component analysis, with an emphasis on the deep radial and calcified cartilage. METHODS:Ten patellar samples were imaged using two-dimensional (2D) UTE and Car-Purcell-Meiboom-Gill (CPMG) sequences. UTE image...

journal_title：Osteoarthritis and cartilage

authors： Shao H,Chang EY,Pauli C,Zanganeh S,Bae W,Chung CB,Tang G,Du J

更新日期：2016-02-01 00:00:00

abstract：OBJECTIVES:The etiology of degenerative meniscus tear is unclear but could be related to a generalized osteoarthritic disease process. We studied whether radiographic hand osteoarthritis (OA) is associated with meniscus damage. METHODS:We examined 974 persons aged 50-90 years drawn via census tract data and random-dig...

journal_title：Osteoarthritis and cartilage

authors： Englund M,Haugen IK,Guermazi A,Roemer FW,Niu J,Neogi T,Aliabadi P,Felson DT

更新日期：2016-02-01 00:00:00

abstract：:Motivated by the conceptual framework of multi-scale biomechanics, this narrative review highlights recent major advances with a focus on gait and joint kinematics, then tissue-level mechanics, cell mechanics and mechanotransduction, matrix mechanics, and finally the nanoscale mechanics of matrix macromolecules. A lit...

journal_title：Osteoarthritis and cartilage

authors： Varady NH,Grodzinsky AJ

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:To investigate the efficacy and feasibility of progressive explosive-type resistance training (RT) in patients with osteoarthritis (OA) of the hip scheduled for total hip arthroplasty (THA). METHOD:Randomized controlled trial (1:1) in patients diagnosed with hip OA and scheduled for THA. The intervention gro...

journal_title：Osteoarthritis and cartilage

authors： Hermann A,Holsgaard-Larsen A,Zerahn B,Mejdahl S,Overgaard S

更新日期：2016-01-01 00:00:00

abstract：OBJECTIVE:The European Society on Clinical and Economic aspects of Osteoporosis and Osteoarthritis (ESCEO) organised a working group to evaluate the need for updating the current European guideline on clinical investigation of drugs used in the treatment of osteoarthritis (OA). DESIGN:Areas of potential attention were...

journal_title：Osteoarthritis and cartilage

authors： Reginster JY,Reiter-Niesert S,Bruyère O,Berenbaum F,Brandi ML,Branco J,Devogelaer JP,Herrero-Beaumont G,Kanis J,Maggi S,Maheu E,Richette P,Rizzoli R,Cooper C

更新日期：2015-12-01 00:00:00

abstract：OBJECTIVE:Synovitis associated with osteoarthritis (OA) is directly responsible for several clinical symptoms and reflects OA's structural progression. This study sought to analyze the expression of proinflammatory mediations, including Interleukin (IL)-17 and IL-22, which play key roles in regulating inflammatory proc...

journal_title：Osteoarthritis and cartilage

authors： Deligne C,Casulli S,Pigenet A,Bougault C,Campillo-Gimenez L,Nourissat G,Berenbaum F,Elbim C,Houard X

更新日期：2015-11-01 00:00:00

abstract：:A major objective of this article is to examine the research implications of recently available genome-wide expression profiles of cartilage from human osteoarthritis (OA) joints. We propose that, when viewed in the light of extensive earlier work, this novel data provides a unique opportunity to reorient the design o...

journal_title：Osteoarthritis and cartilage

authors： Sandy JD,Chan DD,Trevino RL,Wimmer MA,Plaas A

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:The purpose of this controlled laboratory study was to determine the efficacy of Interleukin-1 Receptor Antagonist Protein (IRAP) treatment as an early intervention strategy by examining the changes in microRNA and mRNA expression in cartilage in an ex-vivo porcine knee joint impact model. METHODS:Custom imp...

journal_title：Osteoarthritis and cartilage

authors： Genemaras AA,Reiner T,Huang CY,Kaplan L

更新日期：2015-11-01 00:00:00

abstract：OBJECTIVE:The purposes of this study were to assess whether local anesthetics (LAs), such as ropivacaine and bupivacaine, could induce apoptosis of rabbit annulus fibrosus (AF) cells in vitro and further to explore the possible underlying mechanism. METHODS:Rabbit AF cells at second passage were treated with saline so...

journal_title：Osteoarthritis and cartilage

authors： Cai XY,Xia Y,Yang SH,Liu XZ,Shao ZW,Liu YL,Yang W,Xiong LM

更新日期：2015-10-01 00:00:00

abstract：:Animal models of osteoarthritis (OA) are essential tools for investigating the development of the disease on a more rapid timeline than human OA. Mice are particularly useful due to the plethora of genetically modified or inbred mouse strains available. The majority of available mouse models of OA use a joint injury o...

journal_title：Osteoarthritis and cartilage

authors： Christiansen BA,Guilak F,Lockwood KA,Olson SA,Pitsillides AA,Sandell LJ,Silva MJ,van der Meulen MC,Haudenschild DR

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Our objective was to investigate relationships between proximal tibial subchondral bone mineral density (BMD) and nocturnal pain in patients with knee osteoarthritis (OA). METHODS:The preoperative knee of 42 patients booked for knee arthroplasty was scanned using quantitative computed tomography (QCT). Pain ...

journal_title：Osteoarthritis and cartilage

authors： Burnett WD,Kontulainen SA,McLennan CE,Hazel D,Talmo C,Hunter DJ,Wilson DR,Johnston JD

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the movement of the joint and prevent the delamination of tissue-engine...

journal_title：Osteoarthritis and cartilage

authors： Lee WD,Hurtig MB,Pilliar RM,Stanford WL,Kandel RA

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:The aim of this study was to determine a set of measures for the evaluation of balance in patients suffering from hip osteoarthritis (OA) that were both reliable and responsive to change. DESIGN:Three groups of subjects; Healthy, hip OA patients without surgery, and hip OA with surgery (pre and post-surgery)...

journal_title：Osteoarthritis and cartilage

authors： Laroche D,Kubicki A,Stapley PJ,Gremeaux V,Mazalovic K,Maillefert JF,Ornetti P

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Meniscal injuries can lead to mechanical overloading of articular cartilage and eventually to knee osteoarthritis. The objective was to evaluate the potential of contrast enhanced computed tomography (CECT) to image contrast agent (CA) diffusion in human menisci with a clinical cone beam CT scanner. DESIGN:I...

journal_title：Osteoarthritis and cartilage

authors： Honkanen JT,Danso EK,Suomalainen JS,Tiitu V,Korhonen RK,Jurvelin JS,Töyräs J

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:Lateral wedge insoles are a potential simple treatment for medial knee osteoarthritis (OA) patients by reducing the external knee adduction moment (EKAM). However in some patients, an increase in their EKAM is seen. Understanding the role of the ankle joint complex in the response to lateral wedge insoles is ...

journal_title：Osteoarthritis and cartilage

authors： Chapman GJ,Parkes MJ,Forsythe L,Felson DT,Jones RK

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:SIRT6, a member of the sirtuin family of nicotinamide adenine dinucleotide (NAD(+))-dependent protein deacetylases, has been implicated as a key factor in aging-related diseases. However, the role of SIRT6 in chondrocytes has not been fully explored. The purpose of this study was to examine the role of SIRT6 ...

journal_title：Osteoarthritis and cartilage

authors： Nagai K,Matsushita T,Matsuzaki T,Takayama K,Matsumoto T,Kuroda R,Kurosaka M

更新日期：2015-08-01 00:00:00

abstract：OBJECTIVE:This study used a rat model of post-traumatic knee osteoarthritis (OA) created by anterior cruciate ligament transection with partial medial meniscectomy (ACLT + pMMx). In this model, mild to moderate structural changes that are typical of knee OA have been observed within 2 and 8 weeks post-surgery. We aimed...

journal_title：Osteoarthritis and cartilage

authors： Hamilton CB,Pest MA,Pitelka V,Ratneswaran A,Beier F,Chesworth BM

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:Test the hypothesis that greater baseline peak external knee adduction moment (KAM), KAM impulse, and peak external knee flexion moment (KFM) during the stance phase of gait are associated with baseline-to-2-year medial tibiofemoral cartilage damage and bone marrow lesion progression, and cartilage thickness ...

journal_title：Osteoarthritis and cartilage

authors： Chang AH,Moisio KC,Chmiel JS,Eckstein F,Guermazi A,Prasad PV,Zhang Y,Almagor O,Belisle L,Hayes K,Sharma L

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:The prevalence of osteoarthritis (OA) varies between joints. Cartilage in eight different joints was evaluated to elucidate the disparate susceptibilities between joints to post-traumatic OA (PTOA) and provide evidence for joint-specific clinical treatments. The hypothesis was that cartilage in different join...

journal_title：Osteoarthritis and cartilage

authors： Novakofski KD,Berg LC,Bronzini I,Bonnevie ED,Poland SG,Bonassar LJ,Fortier LA

更新日期：2015-07-01 00:00:00

abstract：:In this brief abbreviated review of regulatory issues regarding the development of drugs and or devices for the treatment of osteoarthritis (OA), the steps that are expected by both the Food and Drug Administration (FDA) and the European Medicines Agency (EMA) are discussed. ...

journal_title：Osteoarthritis and cartilage

authors： Simon LS

更新日期：2015-05-01 00:00:00

abstract：:To highlight methodological challenges in the design and conduct of randomized trials of surgical interventions and to propose strategies for addressing these challenges. This paper focuses on three broad areas: enrollment; intervention; and assessment including implications for analysis. For each challenge raised in ...

journal_title：Osteoarthritis and cartilage

authors： Katz JN,Losina E,Lohmander LS

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:To investigate the in vivo role of the IRE1/XBP1 unfolded protein response (UPR) signaling pathway in cartilage. DESIGN:Xbp1(flox/flox).Col2a1-Cre mice (Xbp1(CartΔEx2)), in which XBP1 activity is ablated specifically from cartilage, were analyzed histomorphometrically by Alizarin red/Alcian blue skeletal pre...

journal_title：Osteoarthritis and cartilage

authors： Cameron TL,Gresshoff IL,Bell KM,Piróg KA,Sampurno L,Hartley CL,Sanford EM,Wilson R,Ermann J,Boot-Handford RP,Glimcher LH,Briggs MD,Bateman JF

更新日期：2015-04-01 00:00:00

abstract：OBJECTIVE:Recent developments in optical clearing and microscopy technology have enabled the imaging of intact tissues at the millimeter scale to characterize cells via fluorescence labeling. While these techniques have facilitated the three-dimensional (3D) cellular characterization within brain and heart, study of de...

journal_title：Osteoarthritis and cartilage

authors： Neu CP,Novak T,Gilliland KF,Marshall P,Calve S

更新日期：2015-03-01 00:00:00